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Figure 1 In addition to the splice variants, GR has eight alternative translation initiation sites in exon 2, arising from leaky ribosomal shunting of the mRNA (20)

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Its primary function is in tissue repair: it promotes actin polymerization (required for cell movement), upregulates anti-inflammatory proteins, and stimulates the migration of keratinocytes and endothelial cells that are needed to close and repair damaged tissue

This dual action may lead to greater weight loss in some patients and potentially offer additional metabolic benefits

Soltani Khaboushan A, Yazdanpanah N, Rezaei N