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Therefore, further in-depth investigations into the intrinsic therapeutic mechanisms of the KD in different diseases are needed, as it will not only provide insights into disease pathogenesis from new perspectives, but also lead to the identification of key intermediate biochemical pathways, molecules, and/or other factors, such as gut microbes, that govern the KD treatment-related effects, and these can be utilized as promising targets for drug design or the development of novel customized interventional strategies to mirror the effects of KD

If long-term exposure to a high iodine environment may increase the immunogenicity of thyroglobulin and then activate the autoimmune reaction, leading to the destruction of thyroid tissue [123]

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2.2 Outcomes and other collected variables S-5-HT levels and behavioral fatigue levels had each been recorded twice, once before and once after the L-carnitine challenge