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Contrasting effects of lixisenatide and liraglutide on postprandial glycemic control, gastric emptying, and safety parameters in patients with type 2 diabetes on optimized insulin glargine with or without metformin: a randomized, open-label trial

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Moreover, factors such as fluid dynamics, pH, and disease-induced pathological alterations in the brains microenvironment (i.e., changes in enzymatic activity, impairment in vascular function, and inflammation) can significantly influence drug distribution and efficacy (Nance et al., 2022)