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Importantly, istradefylline exhibited powerful increases in locomotor activity and potentiated dopaminergic agonist motor effects in animal models of PD (Table 1) [15]

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Maintaining a rotation schedulesuch as alternating between different quadrants of the abdomen or switching between anatomical sitesallows previously used areas to heal fully and reduces the risk of localised hypersensitivity reactions

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Mild, transient lightheadedness can often be managed with hydration, gradual position changes, and dietary modifications while continuing tirzepatide

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