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Multicenter Study

SS-31 40mg A mitochondria-targeted tetrapeptide that binds cardiolipin on the inner mitochondrial membrane, preserving electron transport chain function and reducing reactive oxygen species approved in 2024 as elamipretide (Forzinity) for Barth syndrome

Stacking aggressive calorie restriction on top risks severe muscle loss and rebound when you eventually taper

Point estimates for the treatment effect by tenth of propensity score did not follow any clear pattern and were largely close to the null with wide and overlapping confidence intervals for most tenths (supplementary table S15)