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Figure 1 In the cytoplasm, NADPH oxidases (NOXs) are crucial in maintaining cellular redox balance ( in vivo exposure of renal tubular cells to oxalic acid triggers reactive oxygen species (ROS) production via the TGF-1-NADPH-ROS pathway ( 2.2 Physiological and pathological effects of reactive oxygen species The role of ROS as crucial signaling molecules in cell proliferation and survival has been well established ( Organisms have developed numerous antioxidant defense systems to mitigate damage from ROS