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Additionally, mazdutide has been tested in head-to-head trials against semaglutide, providing insight into how it performs against the most widely used GLP-1 agonist

Insurers also point to inconsistent use of the medications

Some studies show that up to 40% of the weight loss observed in patients on semaglutide is attributable to loss of lean muscle mass, which is viewed as a major shortcoming

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The American Society of Anesthesiologists suggests withholding GLP-1 medications before elective surgery to reduce the risk of complications, and this is something your doctor can help with, should you have an upcoming operation