Crinecerfont met the primary endpoint with a significant reduction from baseline in the daily GC dose, while maintaining androstenedione at a controlled level, compared to placebo at week 24 (change in GC dose, -27.3% versus -10.3%, respectively
Given the enormity of the challenge of obesity and the lack of adequate treatment options, it seems unfair to consider weight as an indicator of personal value
More serious complications from GLP-1 RAs include an increased risk of thyroid cancer,5 gallbladder disease,23 pancreatitis,6 or gastroparesis.29 Phentermine and topiramate have some similar GI side effects, but both add dry mouth to the picture.24 Topiramate can also cause drowsiness, tremors, and some minor bleeding issues like nosebleeds or excessive menstrual bleeding.25 Testosterone replacement therapy safety Testosterone replacement therapy (TRT) poses several significant risks to those who take these drugs and those who live with the patient
World of Obesity Atlas, World Obesity, 2023
Tirzepatides dual GLP-1R and GIPR agonism may confer distinct anti-inflammatory effects, some of which persist even when neuronal GLP-1R signaling is impaired
