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This isn't necessarily the case for compounded GLP-1s

Pernicious Anemia: Parenteral vitamin B 12is the recommended treatment and will be required for the remainder of the patient's life

Do not initiate if ALT is more than 2.5-times the upper limit of normal, or if there are any other signs of liver disease

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Despite inherent limitations of observational data and potential for residual confounding, the results from these observational analyses support, in line with RCT findings, combining SGLT2is and GLP-1RAs to reduce cardiovascular events in patients with diabetes in routine clinical care [12, 23, 43, 63]