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Although Nrf2 does not directly contribute to aerobic glycolysis, glucose uptake and glycolytic activity are stimulated under the sustained activation of the PI3KAkt signaling (Wieman et al., 2007), thereby increasing the supply of glycolytic intermediates

109 A number of pharmacological agents can be used, although high-quality evidence to support these therapies is currently lacking

Primary outcome measures include assessments of cognition, behavior, ADLs, general health status, A and tau biomarkers in CSF and plasma, MRI, EEG, and oxidative and transmitter biomarkers in the blood

However, maintaining muscle mass while losing weight is still crucial for overall health, metabolic function, and physical strength

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