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The objective of this review is to critically assess the current evidence surrounding their mechanisms of action, clinical indications, efficacy, and safety profiles, with particular emphasis on regulatory and translational considerations

A lower initial proportion of product (UA) to precursor (guanine) measured at baseline was associated with greater improvement in clinical functioning 1 month later ( Figure 4 )

If appropriate, injectable therapies may be included as part of a comprehensive program that may also involve nutrition guidance, lifestyle support, and ongoing clinical monitoring

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