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Although various therapeutic modality including systemic and topical pharmacological and procedural treatments are commonly available for melasma management, however, many of these treatments showed limited clinical response and accompany numerous unwanted adverse drug reactions

The gel is usually applied to the inside of the pinna (a hairless area)

Oral delivery will not only improve patient compliance and broaden access, but it can also cut the manufacturing bill and reduce environmental impact through the elimination of injectable device disposal

Thus, based on the role of oxidative stress in the pathogenesis of GO, a therapy with antioxidant agents has been proposed and a number of studies have been performed, both in vitro and in vivo , which is reviewed here

doi: 10.1016/j.bbi.2023.05.006