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Although these studies do not specifically differentiate between neuronal and astrocytic contributions, it is possible that the modulation of astrocytic A 1 and A 2A receptors may have an impact on the onset and progression of ALS, given the well-established importance of astrocytes in the disease [435]

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The dependence for haem-iron at all stages of NTHi pathogenesis exposes a vulnerability that provides promising targets for the development of new therapies that may disrupt iron uptake (Stites et al., 1999

TREM2 protects from atherosclerosis by limiting necrotic core formation