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The murine model and the explanted heart showed intra-myocyte iron deposition, fibrosis, hypertrophy, oxidative stress, remodeling of Ca 2+ cycling proteins, and metabolic kinases typical of heart failure

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Current Biology , 31 (4), 753765e756

ACS Nano 16 (3), 36473663

The approval was backed by data from the CARTITUDE-4 study, where treatment with Carvykti led to statistically significant and clinically meaningful improvement of progression-free survival compared to two standard of care treatment regimens, according to the companies