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E2f1 floxed ( E2f1 L2/L2 ) mice and rat insulin 2 promoter (RIP)-Cre mice were previously described (31, 39) and then further intercrossed to generate pure mutant RIPcre Tg/0 /E2f1 L2/l2 mice

It is essential to emphasise that these remain investigational applications, and patients should not alter prescribed treatments without medical supervision

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Another important aspect is nutrition, as it was shown that, even when dietary protein intake is sufficient for maintaining nitrogen balance, it may not be sufficient for maintaining cellular GSH, particularly in conditions of oxidative stress

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