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George Engel, who recognized that health and illness are not just the result of biological factors but are also influenced by psychological and social factors

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The neuroprotective effects of incretin receptor agonists are therefore due in part by reducing the chronic inflammation response and helping to normalize insulin sensitization and other growth factor signaling pathways

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Despite the fact that the GIP hormone was the first insulin-stimulating factor discovered in the 1960s, [34] it demonstrated an impaired insulinotropic effect in patients with type 2 diabetes mellitus (T2DM), disappointing incretin enthusiasts