Disclosure: Im a paid contributor to NutritionNC.com and was not compensated by MEDVi for this review
233 Sodium-glucose cotransporter-2 (SGLT2) inhibitors are commonly used for type 2 diabetes treatment, and in recent years, SGLT2 inhibitors canagliflozin has been shown to suppress IL-6 and IL-1 levels and MPO enzyme activity in the colon of UC rats by downregulating the expression of NF-B p65, thereby reducing colonic inflammatory cell infiltration and oxidative stress
Weight management can be influenced by many non-modifiable factors like genetic predispositions, age, and ethnicity
This is supported by a recent study that showed an age-dependent decline in both circulating acyl-ghrelin and growth hormone levels in older adults (aged 62-74 years, BMI range 20.9-29 kg/m 2 ) compared to young adults (aged 18-28 years, BMI range 20.6-26.2 kg/m 2 ) (470)
ATTAIN-1 (NCT05869903) The key trial for the obesity indication, ATTAIN-1 randomized 3,127 adults with obesity or overweight (without diabetes) to orforglipron 6 mg, 12 mg, or 36 mg versus placebo for 72 weeks
