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Current medications like Ozempic or Zepbound only hit one or two of those pathways, which is likely why early data is showing more dramatic results. New research on retatrutide benefits for weight loss According to NBC News , the newest phase 3 clinical trial found that people taking retatrutide lost up to 85 pounds, essentially 30 percent of their body weight, which is not too dissimilar to the percentage of body weight people lose after bariatric surgery, which is 25 to 35 percent within one to two years, per NBC News referencing data from Circulation Research