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Treatment typically begins with a low starting dose , which is gradually increased every 14 weeks (depending on the agent) until the target maintenance dose is reached or the maximum tolerated dose is achieved

In cultured bovine PAECs, cigarette smoke extract caused disruption of focal adhesion complexes, F-actin fibers, and adherens junctions and decreased activities of RhoA and focal adhesion kinase [189]

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Fibroblast Activation

Compounded drugs are not FDA-approved, and compounded drugs should only be used in patients whose medical needs cannot be met by an FDA-approved drug