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10.1021/acs.analchem.1c02199 35 LewisJ

Dr Catrise Austin, a cosmetic dentist and author, has described it as "a catch-all phrase describing the sudden onset of dental decay, sensitivity, and even tooth loss in patients on these medications." The American Dental Association addressed the topic at SmileCon 2025, where Dr Kimberly Sanders presented findings on how these newer diabetes and weight loss drugs are reshaping dental care

Further studies in Per2Luc knock-in mice revealed that chronic light-dark disruption elevated pro-inflammatory cytokines (e.g., IL1, IL6, GM-CSF) and impaired host resilience to endotoxin challenge 126