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Clinical trials show tirzepatide produces 2022% weight loss versus 1518% for semaglutide at comparable doses, making it a logical next step for plateau-resistant patients

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nutrition, activity, behavioural strategies) as critical to maintaining outcomes 15

Understanding these mechanisms helps patients and providers make informed decisions about whether this therapy supports long-term metabolic health

Although there was a slight increase in oral semaglutide exposure when taken in combination with omeprazole (possibly due to the increase in gastric pH), the increase observed was not statistically significant and was considered by the investigators to likely not be clinically relevant