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X-2 and microsomal prostaglandin E synthase-1 (mPGES-1) are responsible for the overproduction of prostaglandin E2 (PGE2), which may affect joint integrity through EP4 receptor activation

This neuro-hormone could also elevate levels of antioxidant enzymes (i.e., SOD, CAT, GSH and GPx), and inhibit detrimental effects of NLRP3 inflammasome 659