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[PubMed: 36321995] (41 year old woman developed fatigue 2 months after starting ashwagandha and progesterone and stopped therapy but continued to have symptoms and then jaundice one month later [bilirubin 10.4 rising to 24.6 mg/dL, ALT 3400 U/L, Alk P 102 U/L] and 10 days later with progressive hepatic failure [encephalopathy and INR 6.2], undergoing successful emergency liver transplantation)

Because most trials included in the analysis did not extend beyond 24 weeks, the risk of suicidal thoughts or behavior beyond 24 weeks could not be assessed

It can activate AMPK which helps cells take up glucose and use energy more efficiently

The abdomen, thigh, and arm are good spots

Copper peptides GHK-CU similarly target collagen synthesis through different mechanisms and are sometimes used alongside GLP-1 therapy for skin quality