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It improves insulin sensitivity, has a modest effect on appetite, and has decades of safety data behind it

If youre exploring GLP-1s, you may now be weighing the differences between the GLP-1 pill vs injection

Odah T, Vattikonda A, Stark M, et al

Antiplatelet Agents These drugs, including aspirin and clopidogrel, prevent blood cells (platelets) from sticking together and forming clots and can also lead to easier bleeding and bruising

Before the company applied to the FDA for the drug to be approved for obesity, Knudsen and her colleagues 'developed a new methodology to show how [GLP-1] drugs exert their effect on the brain by working on the circumventricular organs and communicating further into the hypothalamus, among other effects.' This was designed to illustrate how GLP-1 worked in 'well- defined neurons in the hypothalamus, in the hindbrain, and in the reward centers.' Their rationale for developing the method was because 'It was very important to show that these medicines work on defined brain circuits and not ones that may be related to psychiatric or cardiovascular side effects, for example' (Nair