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Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist used for chronic weight management, along with a reduced calorie diet and increased physical activity, for people with an initial body mass index (BMI) of: 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, dyslipidemia, obstructive sleep apnea or cardiovascular disease)

The project was supported by NIH grants RO1DK 55478 (MWH) and USDA/ARS 6250-5100 (MWH), and the Marilyn Fishman Endocrine Fellows Foundation grant (STC)

doi:10.1007/s43032-021-00813-x 269

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