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67 Although the prevalence of solar lentigines increases with age, they can develop in fair-skinned children who have had significant sun exposure, especially on the shoulders following severe sunburns

Mugale et al., 2024), yet many plant-based compounds, especially alkaloids, saponins, and anthraquinones, can cause organ-specific toxicity and genotoxicity, may alter drug metabolism, and exacerbate adverse effects (Quan et al., 2020