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These include: Nausea (most common, particularly at higher doses) Vomiting Diarrhoea Constipation Decreased appetite Gastrointestinal events were generally mild to moderate in severity and tended to resolve as participants adapted to each dose level

This predicts that the K D approach a plateau close to the value recorded for a single histidine residue when the linker is very long - and by extrapolation the ROS production would decrease similarly

doi: 10.2337/dc09-1825 101 SchwetzVLibrizziRTrummerCTheilerGStieglerCPieberTRet al

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