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According to Novo Nordisk prescribing information, similar exposure is achieved across injection sites, including the abdomen, thigh, and upper arm, making differences between these sites clinically minor

If fatigue persists beyond six weeks or worsens over time, it may signal inadequate nutrition, dehydration, or an underlying thyroid condition rather than a direct medication effect

Some people may have mild reactions at the injection site, like redness or irritation

Therefore, we will maintain the current coding mechanism for these products and will direct the Medicare Administrative Contractors to determine appropriate payment, which is generally consistent with how these products are currently paid

Managing Pain, Bruising, and Side Effects at Injection Sites Mild bruising and temporary soreness are normal after semaglutide injection and typically resolve within 48 hours