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Garvey WT, Mechanick JI, Brett EM et al (2016) American Association of Clinical Endocrinologists and American College of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity
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It produces inflammatory cytokines
The presence of these damaged mitochondria is associated with reduced membrane potential (41), which further impairs ETC efficiency and elevates ROS production (42)
Therefore, the acidic residues of p53 TAD appear to have no significant impact on its interaction with the FOXO4 FHD, as these residues primarily contribute to DNA selectivity rather than binding to the FOXO4 FHD
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