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Konig SA, Siemes H, Blaker F, Boenigk E, Gross-Selbeck G, Hanefeld F, Haas N, Kohler B, Koelfen W, Korinthenberg R, et al .: Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities
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Glucose itself does not seem to directly modulate the catalytic activity of DPP-4, as shown in vitro , by incubating the enzyme with high concentrations of glucose ( in vitro , although, interestingly, not in macrovascular (human aortic) endothelial cells ( On the other hand, T2DM is often associated with increased body mass index (BMI), and other studies have suggested that levels of plasma DPP-4 activity actually correlate better with clinical parameters of obesity rather than of T2DM and glucose per se
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