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INY-767(FXR/TGR5 double agonist), INT-777(selective TGR5 agonist), and OCA (selective FXR agonist) can improve proteinuria, alleviate podocyte injury, inhibit renal fatty acid and cholesterol metabolism, and reduce fibrosis-related protein production in diabetic and high-fat obese mice (72)

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The Diamine Oxidase Gene Is Associated with Hypersensitivity Response to Non-Steroidal Anti-Inflammatory Drugs. PLoS ONE, vol

95% CI: 12.40 to 0.07 kg

Gradual titration is critical to minimize gastrointestinal side effects [6]