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STEP-5 extended follow-up to 104 weeks and found that patients who continued semaglutide maintained a 15.2% mean weight reduction, while those who switched to placebo regained roughly two-thirds of lost weight by week 104

Eur Heart J (2014) 35(18):121521.10.1093/eurheartj/ehs23 97 LindenmayerJPNasrallahHPucciMJamesSCitromeL

However, the process of making ATP also produces reactive oxygen species (ROS), such as hydrogen peroxide, which can damage the cell at higher levels

doi:10.4093/dmj.2022.0221 20

Compared to patients treated for diabetes with a non-GLP-1 medication, GLP-1 use was associated with 14% reduced risk of developing any substance use disorder