Introduction Neurobehavioral and metabolic effects of GLP-1 RAs How GLP-1 RAs affect appetite Changes in cravings, mood, and behavior How GLP-1 drugs may reshape addiction pathways Clinical and public health implications Conclusions References Further reading The widely used obesity and diabetes GLP-1 drugs may do far more than reduce weight
Patients usually start losing weight within the first month, even at the starting dose of 0.25 mg
Eating several pounds of watermelon a daywith nothing elsemeans consuming large amounts of fructose without the protein, fat, or fiber to balance it, which can cause digestive discomfort, blood sugar swings, and electrolyte issues even in the short term
however, treatment with liraglutide was able to rescue some of this impairment, indicating that GLP-1R agonism may help restore learning capacity (Hanssen et al., 2023)
The glucose-dependent nature of this effect reduces the risk of hypoglycemia