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A recent meta-analysis assessing the effect of antidiabetic medications versus placebo in the treatment of acute depressive episodes did not support their efficacy in treating unipolar and bipolar depression, possibly because of the high heterogeneity of retained studies [165]

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The internal production of glutathione can be influenced by several factors: The availability of the three amino acids (especially cysteine)

Therefore, iron has a significant role in enhancing cellular ferroptosis sensitivity ( 2+ ) generated through intestinal absorption or degradation by red blood cells is oxidized to trivalent iron (Fe 3+ ), which becomes circulating iron by binding transferrin (TF) to form TF-Fe 3+ (Yang and Stockwell, 2008)