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Check ferritin, serum iron, TIBC, and transferrin saturation at baseline and every 6 months

Point mutations in SNCA are believed to disrupt protein folding and promote aggregation [160]

As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5

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Manufacturing occurs in facilities that undergo continuous FDA inspection with validated processes that ensure batch-to-batch consistency