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These conformational features created a well-defined GLP-1R pocket for GLP-1(9-36) with a total interface area of 1,891 2 , significantly lower than that of GLP-1(7-36) (3,316 2 ), consistent with its weak potency ( Fig

Tirzepatide is a cutting-edge weight loss injection that works by imitating two essential hormones naturally responsible for regulating appetite and blood glucose levels: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

Hypotaurine dehydrogenase catalyzes the further oxidation of the hypotaurine produced, resulting in the formation of taurine (106, 107)

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