The data presented so far, however, strongly suggests that retatrutide could become a transformative therapy in the fight against obesity
A consistent finding across relevant studies is that bariatric surgery achieves comparable short-term weight loss in MC4R -deficient patients and non-deficient controls
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The modest benefits reported thus far underscore the need for a better understanding of IGF signaling, which would enable clinicians to identify the subset of patients with the greatest likelihood of attaining benefit from this targeted approach
As with any nutritional advice for individuals with obesity, it is important to consider the whole person, with attention to life stage, activity level, hormones, and comorbidities
