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Nausea was more frequent with tirzepatide vs placebo, especially with tirzepatide 15 mg (OR 5.60 [95% CI 3.12, 10.06]), associated with higher incidence of vomiting (OR 5.50 [95% CI 2.40, 12.59]) and diarrhoea (OR 3.31 [95% CI 1.40, 7.85])
But results may be modest and weight loss tends to be greater at higher doses
This is important since many people discontinue because of their high cost, side effects, or the practical burden of ongoing injections, he said
What helps bloating on semaglutide or tirzepatide