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Furthermore, acitretins ability to reverse-metabolize into etretinate, particularly when combined with alcohol intake, may intensify toxicity by extending systemic exposure

Large reports have shown natural products have strong therapeutic values in promoting mitochondrial biogenetics and energetics, reducing mitochondrial ROS, enhancing mitophagy, and regulating mitochondrial dynamics (Mu et al., 2020

Therefore it is essential to investigate the effect of GSH depletion on RPE cells to further elucidate the potentially involved mechanisms