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9 BPC-157 acts primarily at the local injury site

To mitigate this limitation, several strategies have been proposed, such as surface functionalization/coating (e.g., PEGylation, or solgel layers) and dynamic pre-saturation of PDMS with the compound of interest, or the use of alternative fabrication methods and materials, like thermoplastics (e.g., cyclic olefin copolymer, polymethyl methacrylate) or 3D-printed resins, that exhibit reduced molecular adsorption (79, 8386)

Only 1 in 5 people with opioid use disorder and fewer than 8% of those with alcohol use disorder receive treatment

Expected Weight Loss Trajectory At the 12mg dose, the average trajectory follows a predictable curve

To overcome these burdens, modern technology attempted to replace conventional treatments by designing smart hybrid nanosystems that can deliver drugs to localized sites to prevent infection by overcoming barriers imposed by biofilms and regulating complex wound microenvironment, thus promoting tissue regeneration in the wounded site