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A new mechanism for bile acid diarrhea: Defective feedback inhibition of bile acid biosynthesis

[DOI] [PubMed] [Google Scholar] 13.He F., Li J., Liu Z., Chuang C.-C., Yang W., Zuo L

GSH synthesis is limited by gGC availability, determined by GCL activity [22], which can be inhibited by GSH [20], or limited by Cys availability [19]

79 Furthermore, activation of the nuclear factor E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1(KEAP-1)-GPX4 pathway also exhibits excellent antiferroptosis effects by inhibiting lipid peroxidation by upregulation of GPX4 and SLC7A11 transcription and increases in NADPH and GSH levels

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