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The GI symptom spectrum The FDA prescribing information for Wegovy lists the following GI side effect rates at the 2.4mg dose: Nausea: 44% of patients

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This led to the development of exenatide and subsequent GLP-1 receptor agonists, which are now widely used to treat type 2 diabetes by enhancing insulin secretion, slowing gastric emptying, and reducing appetite

Some small studies and anecdotal clinical reports suggest that the combination may lead to a more significant reduction in body weight than either drug alone