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Some clinicians recommend temporarily reducing or discontinuing berberine during tirzepatide initiation and dose escalation, then cautiously reintroducing it once the tirzepatide dose is stable and tolerability is established

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The term "reduced" refers to the chemical state of the molecule

The Green List is a roster of foreign bulk-drug-substance manufacturers that the FDA has determined comply with current good manufacturing practice for GLP-1 receptor agonist active ingredients

Diabetes Care 41 , 10681075 (2018)