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The significant cell damage and loss result in decreased dopamine concentration within the striatum and the dysfunction of the nigrostriatal pathway

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In contrast, FINO2 both indirectly inhibits the enzyme function of GPX4 and directly oxidizes iron, ultimately leading to extensive lipid peroxidation [186, 187]

Methods 203:575583 Sherwood R, Takahashi TS, Jallepalli PV (2010) Sister acts: coordinating DNA replication and cohesion establishment