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Description

72,73 The increase in intracellular cAMP after GLP-1R activation then activates a guanine nucleotide exchange factor called Epac (Exchange Protein directly Activated by cAMP), which induces PI3K activation followed by Akt phosphorylation

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F., Holst, P

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Inflamm Bowel Dis 15: 16781685, 2009

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SPMs, PRMs, phenomenal

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Understanding this process reveals exactly where peptides intervene and why they can be so effective

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