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Carey MD Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore

Glucagon-like peptide 1 is produced in the gut as a result of eating food and it appears that its primary roles are to inhibit the production of glucagon and to promote the production of insulin

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Their primary therapeutic effects include glucose-dependent insulin secretion from pancreatic beta cells, suppression of inappropriate glucagon release, delayed gastric emptying, and reduced appetite through central nervous system pathways