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Gabery et al., 2020)

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(2011), burst firing of VTA dopaminergic neurons may operate as a teaching signal. For example, in the case of food intake, when rats are presented with a highly palatable food for the first time, this triggers dopamine release in the Acc (shell), whereas repeated exposure to the same palatable food blunts the dopamine response despite avid consumption

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The risk is minimised when metformin is used appropriately, the dosage is adjusted according to kidney function, and contraindications are considered [198]

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