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If standardized peptide formulations can be verified and administered within controlled protocols, these agents may represent a future adjunct to evidence-based perioperative care, particularly in populations undergoing TJA where wound healing, metabolic health, and inflammatory regulation strongly influence outcomes

During obesity-induced adipose tissue remodeling, abnormal secretion of proinflammatory factors and adipokines promotes tumor cell proliferation, invasion, and metastasis, accelerating tumor progression

& Ginsberg, H