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Real-time RT-PCR findings revealed that the odonto/osteogenic genes including DMP1, DSPP, RUNX2, OSX and OCN obviously decreased in IGF-1-treated SCAPs accompanying with the hsa-let-7c over-expression, in which the expression of DSPP and OSX reduced at day 3, while COL-I, RUNX2, OCN, DMP1 reduced at day 7 (Fig