optionally convertible by holder and issuer into common stock of Wells Fargo & Company 1 Coupon: 7.50% Final Maturity: Perpetual Payment Dates: 03/15, 06/15, 09/15, 12/15 Record Dates: Last day of month preceding payment date Non-Cumulative Perpetual Preferred Series Y CUSIP: 94988U656 Amount: $690 million Announcement Date: 04/17/2017 Callable on or after: 06/15/2022 Coupon: 5.625% Final Maturity: Perpetual Payment Dates: 03/15, 06/15, 09/15, 12/15 Record Dates: Last business day of month preceding payment date Non-Cumulative Perpetual Preferred Series Z CUSIP: 94988U151 Amount: $2,012.5 million Announcement Date: 01/15/2020 Callable on or after: 03/15/2025 Coupon: 4.75% Final Maturity: Perpetual Payment Dates: 03/15, 06/15, 09/15, 12/15 Record Dates: Last business day of month preceding payment date Non-Cumulative Perpetual Preferred Series AA CUSIP: 94988U128 Amount: $1,170 million Announcement Date: 10/21/2020 Callable on or after: 12/15/2025 Coupon: 4.70% Final Maturity: Perpetual Payment Dates: 03/15, 06/15, 09/15, 12/15 Record Dates: Last business day of month preceding payment date Non-Cumulative Perpetual Preferred Series CC CUSIP: 95002Y202 Amount: $1,050 million Announcement Date: 01/25/2021 Callable on or after: 03/15/2026 Coupon: 4.375% Final Maturity: Perpetual Payment Dates: 03/15, 06/15, 09/15, 12/15 Record Dates: Last business day of month preceding payment date Non-Cumulative Perpetual Preferred Series DD CUSIP: 95002Y400 Amount: $1,250 million Announcement Date: 07/20/2021 Callable on or after: 09/15/2026 Coupon: 4.25% Final Maturity: Perpetual Payment Dates: 03/15, 06/15, 09/15, 12/15 Record Dates: Last business day of month preceding payment date Non-Cumulative Perpetual Preferred Series EE CUSIP: 95002YAA1 Amount: $1,725 million Announcement Date: 07/17/2023 Callable on or after: 09/15/2028 Coupon: 7.625% to 9/15/28

Keywords: GLP-1, Semaglutide, Diabetes mellitus, Insulin resistance, Inflammation Introduction The global prevalence of diabetes mellitus (DM) is rapidly increasing [1]
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CBT-ED addresses the cognitive distortions and behavioural patterns that maintain binge eating, including rigid dietary rules, negative body image and emotional eating triggers
White bread, sugary snacks, and ultra-processed pastries spike your blood sugar levels and offer little nutritional payoff